The original statute of the Italian Society stated that the headquarters of the Society should be situated in the city where the President in office resides. These arrangements, which did not foresee permanent headquarters, were intended to avoid preferences, by the society, of specific pre-unitary states .

After the Unification of Italy, the president in office at that time, Sen. Francesco Brioschi, suggests that the headquarters of the Society be transferred to Rome, recent capital of Italy, and expresses his wish for a merger with the National Academy of Lincei, of which Sen. Brioschi was president for many years.

In 1875, Brioschi’s successor, Arcangelo Scacchi is able to transfer the headquarters of the Italian Society from Modena to Rome at the EngineeringSchool in San Pietro in Vincoli.

The Headquarters of the Society remain in San Pietro in Vincoli until 1934. In that year the fascist government under a decree with the force of law orders the transfer of the headquarters to the “Royal Academy of Lincei”. Although the Society is formally headquartered at Villa Farnesina, in 1935 the archives and part of the library are transferred, by Guido Castelnuovo, to the School of Mathematics at the City University of Rome.

In 1951, the National Academy of XL is hosted by the Istituto Superiore di Sanità in Via del Castro Laurenziano, thanks to the Academy administrator Domenico Marotta, at that time director of the Institute.

In 1965 the Academy must abandon the Institute and is transferred in the offices of the National Bank of Agriculture in Via del Corso.

In 1968 the Academy is transferred in an apartment in Via Nazionale.

In 1975, thanks to Academy President Beniamino Segre, the Academy is transferred to the Palazzo della Civiltà del Lavoro at EUR district and will remain there for twenty years.

In 1995 the Academy is forced to leave Palazzo della Civiltà del Lavoro and is transferred temporarily at Villa Lontana in Via Cassia. La Villa è parte del lascito istituito dall’avv. Cesare Tumedei a favore dell’Accademia, con l’obbligo, in qualità di amministratrice, di liquidare il patrimonio e di utilizzare i proventi per l’acquisto di macchinari di cardiologia e nefrologia da destinare agli ospedali romani.

In the year 2000 the National Academy of Sciences XL is transferred permanently at the Villino Rosso in Villa Torlonia. The Villa is provided by the Municipality of Rome and was entirely renovated by the Academy.